EMULGELS: ADVANCING TOPICAL DELIVERY SYSTEMS FOR HYDROPHOBIC DRUGS

Abstract

Emulgels represent an innovative topical drug delivery system, integrating the properties of emulsions and gels to enhance therapeutic efficacy. These formulations combine ease of application with effective drug delivery, offering a non-greasy, spreadable, and aesthetically pleasing alternative to conventional topical treatments. Emulgels excel in delivering hydrophobic drugs, ensuring controlled release and improved bioavailability, making them suitable for dermatological conditions such as acne, eczema, and fungal infections, as well as analgesic applications like Diclofenac Emulgel, which demonstrates a notable Number Needed to Treat of 1.8 for significant pain relief. Their stability surpasses that of traditional emulsions, minimizing issues like phase separation. However, potential drawbacks include skin irritation, allergic reactions, and challenges with bubble entrapment, which may impede drug penetration. Additionally, complex production processes for advanced forms like nanoemulgels can increase costs. Emulgels hold substantial promise for diverse applications, with ongoing research poised to further refine their therapeutic potential.