EVALUATION OF MEMORY-ENHANCING AND NEUROPROTECTIVE EFFECTS OF CHENOPODIUM ALBUM LEAF EXTRACTS IN WISTAR RATS

Abstract

Scopolamine disrupts cholinergic signaling and models Alzheimer-type cognitive loss. Chenopodium album has traditional use for brain function. Ethanolic and aqueous leaf extracts were tested in scopolamine-treated Wistar rats at 250 and 500 mg/kg, with piracetam as reference. Phytochemical screening identified alkaloids, saponins, quinones, coumarins, sugars, and gums. Both extracts reduced oxidative markers (MDA, LDH, nitrite) and restored SDH and GSH. Higher doses produced stronger effects. Findings indicate notable memory-protective and antioxidant activity. Bioactive components such as flavonoids, tannins, diosgenin, quinones, and saponins likely drive the response. Further component-specific work is required.