EXAMINING THE EFFECT OF SODIUM ATPASE ON SPASTIC PARALYSIS IN NORMOTENSIVE RATS INDUCED EXPERIMENTALLY

Abstract

Rats with normal blood pressure weighing 150–180g±2.5g (n=8) were given Suxa (1.08 mg/kg) intramuscularly (i.m.) to induce experimental paralysis. To determine at what doses these medications would cause spastic paralysis that could be sustained without death, a range of dosages from 0.36 to 1.08 mg/kg were utilized. In a similar manner, the effect of dosage response concentrations was investigated, and the time it took to detect paralysis, pain, and death was noted. In certain tests, the drugs' efficacy and response time (RT) were evaluated using doses of Suxa (1.08 mg/kg). The effects of Calotropin (CLT), Abrin (ABN) were then investigated in different trials. The results of these studies showed that the paralysis brought on by Calotropin (CLT) and Abrin (ABN) had a reversal effect at the concentrations used in this inquiry. The study sought to determine how these drugs interacted with long-term experimental paralysis in rodents.