Copper Mobilization by the Proteins at Various pH Values

Abstract

The paper investigates reaction of certain relevant proteins with copper ions in response to changes in pH. The effect of pH on copper mobilization by proteins in vitro conditions and serum copper/iron ratio as a function of pH as well as its connection with pathological alteration are followed. This experiment showed that proteins mobilize copper ions by different mechanisms depending on pH. The possible relationship between Alzheimer’s disease, Wilson’s disease, prion diseases, cirrhosis, Down syndrome and pH-dependent copper-protein complex is also considered.