BIOLOGICALLY POTENT COMPLEXEX DERIVED FROM β-DIKETONE DERIVATIVE

Abstract

A new Schiff base ligand, and its Zn (II),Cu(II), Co (II), complexes were synthesised and characterized by various spectroscopic techniques.Complexes were derived from condensatation of heterocyclic aldehyde, acetyl acetone and substituted thiadazole. New  complexes were characterized by NMR, Infrared spectra, elemental analysis and magnetic moment reveal that metal ion is coordinated in tridentate nature .It was also studied using UV-Visible, TGA and XRD. TGA analysis used for thermodynamic and kinetic study. The antimicrobial activity of the ligand and its complexes was screened against a variety of pathogenic bacteria and fungi including Escherichia coli, Staphylococcus aureus and Candida albicans. The data obtained revealed that the metal ion in the complexes enhanced the antimicrobial activity compared to the free ligand.