THE RELATIONSHIP BETWEEN TYPE 2 DIABETES MELLITUS AND GUT MICROBIOME

Abstract

About 95% of diabetes patients are type 2 diabetes mellitus (T2DM), a prevalent metabolic illness marked by insulin resistance and hyperglycemia. The variables that lead to the establishment of T2DM are still unclear. Numerous research has looked into the pathophysiology of metabolic illnesses and the critical role that gut bacteria plays in modulating ghost metabolism. The understanding of how gut microbiota function at the cellular and molecular levels has advanced significantly during the last 20 years. The consequences of gut microbiota dysbiosis establishment of type 2 diabetes mellitus may therefore be better understood by knowing the variables influencing the makeup of gut microbes and their metabolites, which interact with host cells and preserve normal physiology. In this article, we provide recent insights regarding the mechanisms regulating the diversity of gut microbiota as well as the role of gut microbiota in glucose metabolism (described in human model and animal model).