IN SILICO EVALUATION OF SINAPIC ACID FROM CAYRATIA AURICULATA AND GIBBERELLIC ACID FROM DYSOXYLUM MALABARICUM AS POTENTIAL HEPATOPROTECTIVE AGENTS AGAINST HEPATOTOXICITY

Abstract

Hepatotoxicity, which is the toxic damage to the liver, is a major health problem throughout the world, being attributed to drugs, alcohol as well as environmental toxins. This paper examines hepatoprotective properties of two compounds found in plants, sinapic acid in Cayratia auriculata and gibberellic acid in Dysoxylum malabaricum. Both of those compounds have been shown to possess anti-inflammatory and antioxidant activity, whereas sinapic acid has been demonstrated as capable of decreasing oxidative stress and liver fibrosis, whereas gibberellic acid is known to stimulate liver regeneration. This paper also constructs in silico molecular docking to assess the binding affinity of the compounds to carnitine O-palmitoyltransferase 2 (CPT2), a key enzyme of fatty acid metabolism. The findings show that sinapic acid has a very strong affinity with CPT2, which suggests it can be used as a drug. The results would give grounds into the use of plant-based hepatoprotective drugs against hepatotoxicity.